Inhibitors of phospholipase enzymes

A compound of the formula:

• wherein:
• R1 and R1′ are independently selected from the group consisting of H, C1-C6 alkyl, —Z—C1-C6 alkyl, phenyl, —(CH2)n—Z—(CH2)n-phenyl, benzyl, —(CH2)n—Z—(CH2)n-benzyl, naphthyl, —(CH2)n—Z—(CH2)n-napthyl, pyrimidinyl, and —(CH2)n—Z—(CH2)n-pyrimidinyl, wherein the alkyl, phenyl, benzyl, napthyl and pyrimidinyl groups may be optionally substituted by from 1 to 3 substituents selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, —NO2, —NH2, —CN, —CF3, and —OH;
• Z is O or S;
• n is an integer from 0 to 3;
• R2 is selected from the group consisting of H, halogen, —CF3, —OH, —C1-C10 alkyl, C1—C10 alkoxy, —CHO, —CN, —NO2, —NH2, —NH—C1-C6 alkyl, —N(C1-C6 alkyl)2, —NH—SO2—C1-C6 alkyl, and —SO2-C1-C6 alkyl;
• R3 is selected from the group consisting of H, halogen, —CF3, —OH, C1-C10 alkoxy, —CHO, —CN, —NO2, —NH2, —NH—C1-C6 alkyl, —N(C1-C6 alkyl)2, —NH—SO2—C1-C6 alkyl, and —SO2—C1-C6 alkyl;
• n in each appearance is independently an integer selected from 0-3;
• R4 is
• R12 is selected from the group consisting of H, —CF3, C1-C6 alkyl, —(CH2)n—C3-C6 cycloalkyl, phenyl, and benzyl, the cycloalkyl, phenyl or benzyl groups being optionally substituted by from 1 to 3 groups selected from the group consisting of halogen, —CF3, —OH, —COOH, —(CH2)n—COOH, —(CH2)n—C(O)—COOH, —C1-C6 alkyl, —O—C1-C6 alkyl, —NH(C1-C6 alkyl), and —N(C1-C6 alkyl)2;
• R5 is selected from the group consisting of 4-{[3,5-bis(trifluoromethyl)phenoxy]-methyl}benzyl, 3-[3,5-bis(trifluoromethyl)phenoxy]propyl, 2,4-bis(trifluoromethyl)benzyl, 4-chlorobenzyl, 2-naphthylmethyl, 4-benzylbenzyl, and 3-[3,5-bis(trifluoromethyl)phenoxy]-propyl;
• provided that R1, R1′, R2 and R3 are not all H, or a pharmaceutically acceptable salt thereof.