Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating
AssigneeBausch & Lomb Incorporated
InventorsPaul L. Valint, Jr., Daniel M. Ammon, Jr., Joseph A. McGee, George L. Grobe, III, Richard M. Ozark
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Abstract
The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.
Claims32
A method for treating the surface of a silicone medical device comprising the following steps:
- (a) subjecting the surface of the silicone medical device to a plasma-polymerization reaction in a hydrocarbon-containing atmosphere to form a polymeric carbonaceous layer on the surface of the silicone medical device having a thickness of 50 to 500 Angstroms;
- (b) forming reactive functionalities on the surface of the carbonaceous layer;
- and
- (c) exposing the surface of the silicone medical device to a solution of a hydrophilic reactive polymer having complementary reactive functionalities on the carbonaceous layer, thereby forming a biocompatible surface on the silicone medical device,
- wherein the silicone medical device is a silicone contact lens or silicone intraocular device.
The method of claim 5, wherein the plasma pretreatment is conducted at 10 to 1000 watts for a period of 1 to 10 minutes at a pressure of 0.1 to 1.0 torr.
A method for treating the surface of a silicone medical device comprising the following steps:
- (a) subjecting the surface of the silicone medical device to a plasma-polymerization reaction in a hydrocarbon-containing atmosphere to form a polymeric carbonaceous layer on the surface of the silicone medical device having a thickness of 50 to 500 Angstroms;
- (b) forming reactive functionalities on the surface of the carbonaceous layer by plasma treatment with a nitrogen-containing gas or gaseous mixture;
- and
- (c) exposing the surface of the silicone medical device to a solution of a hydrophilic reactive polymer having complementary reactive functionalities on the carbonaceous layer, thereby forming a biocompatible surface on the silicone medical device.
A method for treating the surface of a silicone medical device comprising the following steps:
- (a) subjecting the surface of the silicone medical device to a plasma-polymerization reaction in a hydrocarbon-containing atmosphere to form a polymeric carbonaceous layer on the surface of the lens having a thickness of 50 to 500 Angstroms;
- (b) forming reactive functionalities on the surface of the carbonaceous layer;
- and exposing the surface of the silicone medical device to a solution of a hydrophilic reactive polymer selected from the group consisting of glycidyl methacrylate, maleic anhydride, itaconic anhydride, and isocyanotmethacrylate having complementary reactive functionalities along the polymer chain in order to covalently bond with said reactive functionalities on the carbonaceous layer, thereby forming a biocompatible surface on the silicone medical device.
A silicone medical device including a hydrophilic surface, wherein said surface comprises:
- (a) a carbonaceous layer on the surface of the medical device;
- and
- (b) hydrophilic polymer chains attached to the carbonaceous layer wherein the points of attachment are the result of the reaction of complementary reactive functionalities in monomeric units along the hydrophilic polymers with reactive functionalities on the carbonaceous layer wherein hydrophilic polymer chains attached to the carbonaceous layer are the result of the reaction of a mixture of polymers comprising (a) a first hydrophilic reactive polymer having reactive functionalities in monomeric units along the hydrophilic polymers complementary to reactive functionalities on the carbonaceous layer and, in addition, (b) a second hydrophilic reactive polymer having supplemental reactive functionalities that are reactive with the first hydrophilic reactive polymer and wherein the first hydrophilic reactive polymer is an epoxy-functional polymer and the second hydrophilic reactive polymer is an acid-functional polymer, either simultaneously or sequentially applied to the substrate to be coated.
Dependencies are inferred from the claim text.