Particulate delivery systems and methods of use

A vaccine for eliciting an enhanced immune response in a subject comprising a plurality of microstructures associated with one or more immunoactive agents, wherein said microstructures comprise at least 5% w/w of a biocompatible surfactant selected from the group consisting of saturated and unsaturated lipids, nonionic detergents, nonionic block copolymers, ionic surfactants, cationic surfactants, biocompatible fluorinated surfactants, and combinations thereof,

• wherein said vaccine is formulated so as to be capable of being administered to the respiratory tract of said subject;
• and
• wherein said enhanced immune response is enhanced relative to the immune response elicited by a comparable immunoactive agent delivered via an aqueous carrier in the substantial absence of said microstructures.

A method for providing enhanced active immunization comprising administering to a patient a therapeutically or prophylactically effective amount of a medicament that comprises a plurality of microstructures associated with one or more vaccines,

• wherein said microstructures comprise at least about 5% w/w of a biocompatible surfactant selected from the group consisting of saturated and unsaturated lipids, nonionic detergents, nonionic block copolymers, ionic surfactants, cationic surfactants, biocompatible fluorinated surfactants, and combinations thereof;
• and
• wherein said enhanced active immunization is enhanced relative to the immune response elicited by comparable vaccines delivered via an aqueous carrier in the substantial absence of said microstructures.

A method for providing enhanced passive immunization comprising administering to a patient a therapeutically or prophylactically effective amount of a medicament that comprises a plurality of microstructures associated with one or more immunoglobulins or immunoglobulin-like molecules,

• wherein said microstructures comprise at least about 5% w/w of a biocompatible surfactant selected from the group consisting of saturated and unsaturated lipids, nonionic detergents, nonionic block copolymers, ionic surfactants, cationic surfactants, biocompatible fluorinated surfactants, and combinations thereof;
• and
• wherein said enhanced passive immunization is enhanced relative to the immune response elicited by comparable immunoglobulins or immunoglobulin-like molecules delivered via an aqueous carrier in the substantial absence of said microstructures.

A method for treating an autoimmune disease or disorder comprising administering to a patient a therapeutically or prophylactically effective amount of a medicament that comprises a plurality of microstructures associated with one or more immunomodulators,

• wherein said microstructures comprise at least about 5% w/w of a biocompatible surfactant selected from the group consisting of saturated and unsaturated lipids, nonionic detergents, nonionic block copolymers, ionic surfactants, cationic surfactants, biocompatible fluorinated surfactants, and combinations thereof;
• and
• wherein said treatment for an autoimmune disease or disorder is enhanced relative to the treatment elicited by comparable immunomodulators delivered via an aqueous carrier in the substantial absence of said microstructures.