Controlled release liquid delivery compositions with low initial drug burst
AssigneeAtrix Laboratories, Inc.
InventorsBhagya L. Chandrashekar, Mingxing Zhou, Eileen M. Jarr, Richard L. Dunn
Life of this patent
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Abstract
The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.
Claims13
A polymeric composition for forming a controlled release implant within a body, comprising:
- a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a poly(lactide-co-glycolide)/polyethylene glycol block copolymer;
- and
- a biologically active agent
- wherein the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A polymeric composition for forming a controlled release implant within a body, comprising:
- a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a polymeric controlled release additive that is insoluble in aqueous or body fluids and is a block copolymer of a biocompatible, biodegradable, thermoplastic polymer and polyethylene glycol;
- and
- a biologically active agent;
- wherein the base polymer, controlled release additive and solvent form a solution and the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A polymeric composition for forming a controlled release implant within a body, comprising:
- a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a polymeric controlled release additive that insoluble in aqueous or body fluid and is a block copolymer of a biocompatible, biodegradable, thermoplastic polymer and polyethylene glycol;
- and
- lidocaine HCl
- wherein the base polymer, controlled release additive and solvent form a solution and the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A polymeric composition for forming a controlled release implant within a body, comprising:
- a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a polymeric controlled release additive that insoluble in aqueous or body fluid and is a block copolymer of a biocompatible, biodegradable, thermoplastic polymer and polyethylene glycol;
- and
- floxuridine
- wherein the base polymer, controlled release additive and solvent form a solution and the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A polymeric composition for forming a controlled release implant within a body, comprising:
- a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a polymeric controlled release additive that is insoluble in aqueous or body fluid and is a block copolymer of a biocompatible, biodegradable, thermoplastic polymer and polyethylene glycol;
- and
- leuprolide acetate
- wherein the base polymer, controlled release additive and solvent form a solution and the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A method of forming a controlled release implant in situ within a body, comprising:
- placing a polymeric composition into an implant site within the body, wherein the polymeric composition comprises a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a poly(lactide-co-glycolisde)/polyethylene glycol block copolymer;
- and a biologically active agent,
- wherein the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A method of forming a controlled release implant in situ within a body, comprising:
- placing a polymeric composition into an implant site within the body, wherein the polymeric composition comprises a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a poly(lactide-co-glycolisde)/polyethylene glycol block copolymer;
- and a biologically active agent selected from the group consisting of lidocaine base, lidocaine HCl, floxuridine, and leuprolide acetate,
- wherein the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
A method of forming a controlled release implant in situ within a body, comprising:
- placing a polymeric composition into an implant site within the body, wherein the polymeric composition comprises a biocompatible, biodegradable, thermoplastic base polymer that is insoluble in aqueous or body fluids;
- a biocompatible, organic solvent that is soluble in aqueous or body fluid;
- a polymeric controlled release additive that is insoluble in aqueous or body fluids and is a block copolymer of a biocompatible, biodegradable, thermoplastic polymer and polyethylene glycol;
- and a biologically active agent,
- wherein the base polymer, controlled release additive and solvent form a solution and the polymeric composition is capable of forming the controlled release implant by dissipation or dispersement of the organic solvent within the body.
Dependencies are inferred from the claim text.