Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2
AssigneeMetaproteomics, LLC
InventorsJohn G. Babish, Terrence Howell, Linda Pacioretty
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Abstract
A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
Claims6
A method of inflammation caused by COX-2 in animals comprising administering to an animal suffering symptoms of said inflammation a synergistically effective composition comprising, as a first component, an effective amount of a pharmaceutical grade diterpene triepoxide lactone and an effective amount of a second component selected from the group consisting of a pharmaceutical grade diterpene lactone and a pharmaceutical grade triterpene or derivatives thereof, and continuing said administering of the composition until said symptoms are reduced,
- wherein the synergistically effective composition comprises a ratio of the first component to the second component is between 1:1 to 1:4.
Dependencies are inferred from the claim text.