Method for inhibition of viral morphogenesis
OwnerJeffrey Glenninventor
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Abstract
Viral morphogenesis, production, release or uncoating can be inhibited by effecting inhibition of prenylation of, or inhibition of post-prenylation reactions of, at least one viral protein. The use of inhibitors of prenylation, and post-prenylation reactions, for example, inhibitors of the mevalonate and prenyl group synthesis pathways, inhibitors of prenyl group transferases and mimics of the prenylation target CXXX box are disclosed.
Claims9
A method to treat a viral infection in a subject via inhibiting the prenylation of a protein contained in the virus infecting said subject, which method comprises administering to said subject an agent selected from the group consisting of
- an agent that mimics the amino acid sequence of a “CXXX” (SEQ ID NO:1), “XCXX” (SEQ ID NO:4), “XXCX” (SEQ ID NO:5), or “XXXC” (SEQ ID NO:
- 6) box as it occurs in said viral protein, and
- an inhibitor of a prenyl transferase.
Dependencies are inferred from the claim text.