Methods and systems for applying multi-mode energy to biological samples
AssigneeImarx Therapeutics, Inc.
InventorsEvan C. Unger, Yunqiu Wu, Thomas McCreery
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Abstract
A system for applying energy to cells so as to elicit the formation of pores, to enhance transfection, and/or cell transformation, includes a computer, a plurality of acoustic probes for controllably applying acoustic energy to batches of cells, and a robot operatively for effecting relative movement between the probes and the batches of cells. Preferably, the acoustic energy comprises ultrasonic energy, which is applied in combination with optical or electrical energy to enhance the formation of pores in surface membranes of the cells.
Claims34
A method comprising applying ultrasonic energy in combination with electrical energy to cells to enhance cell uptake of a desired material and to enhance subsequent gene expression, wherein said ultrasonic energy and said electrical energy are applied with a sonoelectroporation transducer comprising electrodes within a transducer ensemble.
An apparatus for application of ultrasonic energy in combination with electrical energy to cells to enhance cell uptake of a desired material comprising a sonoelectroporation transducer comprising electrodes within a transducer ensemble to generate said ultrasonic energy and said electrical energy.
Dependencies are inferred from the claim text.