US 6,627,215 B1 · Devices for improved wound management

Abstract

The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.

Claims31

Dependent claims

A wound dressing comprising:

(a) a solid substrate;
and
(b) an antibacterial formulation comprising a protonated/acidified nucleic acid of up to 100 nucleotides, wherein said protonated/acidified nucleic acid comprises a backbone structure modified from that of naturally occurring nucleic acids, and wherein said protonated/acidified nucleic acid has a pH of about 1.0 to about 4.5 when dissolved in water.

Dependencies are inferred from the claim text.

Devices for improved wound management

Life of this patent

Devices for improved wound management

Life of this patent

Abstract

Claims31