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US 6,627,202 B2Granted
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
AssigneeBiogen, Inc.
InventorKenneth Murray
Life of this patent
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AssigneeBiogen, Inc.
InventorKenneth Murray
Estimating the term…
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV cote antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.
An HBV core antigen particle having multiple immunogen specificities, said particle comprising at least one capsid binding immunogen, said capsid binding immunogen comprising at least one HBV capsid-binding peptide component and at least one immunogenic component.
A method for increasing the immunogenicity of an immunogen comprising the step of linking said immunogen to an HBV core antigen particle through an HBV capsid-binding peptide.
Dependencies are inferred from the claim text.