Cellular matrix
AssigneesVerigen AG, Peter Karl Muller, Peter Behrens, Jurgen Rohwedel, Martin Russlies
InventorsPeter Karl Müller, Peter Behrens, Bruno Giannetti, Jürgen Rohwedel, Martin Russlies
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Abstract
A biocompatible, resorbable Type II collagen-based matrix is reconstituted from solubilized animal cartilage tissue and used in the culture and growth of cells, such as chondrocyte cells. The matrix is produced by isolating cartilage tissue, solubilizing and reconstituting the cartilage to form a fleece-like material, pressing the fleece-like material to form a sheet-like article, and sterilizing the article. An implantable article for cartilage repair includes chondrocyte cells retained on the matrix.
Claims8
A Type II collagen-based matrix comprising reconstituted Type II collagen formed from solubilized articular cartilage tissue, wherein the matrix is fleece-like, implantable in an animal body, and adapted, when disposed in the animal body, to be resorbed into the animal body by natural biological processes.
A reconstituted Type II collagen-based matrix from solubilized articular cartilage tissue produced by the steps of:
- (a) isolating cartilage tissue from an animal;
- (b) solubilizing the tissue;
- (c) reconstituting the tissue;
- (d) crosslinking the tissue;
- (e) lyophilizing the material to form a fleece-like material;
- and
- (f) sterilizing the material to form the matrix.
Dependencies are inferred from the claim text.