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US 6,623,961 B2Granted
Method for selective inactivation of viral replication
AssigneeRigel Pharmaceuticals, Inc.
InventorsVincent J. Miles, Michael B. Mathews, Michael G. Katze, Julia C. Watson, Gary Witherell
Life of this patent
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Abstract
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any interaction of the agent with the component reduces the level of translation of an RNA of the virus.
Claims20
A cell comprising:
- a nucleic acid construct comprising:
- a) a hepatitis internal ribosome entry site (IRES);
- and b) a reporter gene operably linked to said IRES.
Dependencies are inferred from the claim text.