Absorbable adhesive compositions
AssigneeClosure Medical Corporation
InventorsJerry Y. Jonn, John Bobo, Julian Quintero, Jon P. Moseley
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Abstract
A method of treating living tissue includes applying to living tissue a biocompatible adhesive composition containing at least one alkyl ester cyanoacrylate monomer and a polymerization initiator or accelerator, wherein the polymerization initiator or accelerator is a quaternary amine.
Claims72
A method of treating living tissue, comprising:
- applying to living tissue a biocompatible adhesive composition comprising at least one alkyl ester cyanoacrylate monomer and a polymerization initiator or accelerator, wherein said polymerization initiator or accelerator is a quaternary amine,
- wherein said at least one alkyl ester cyanoacrylate monomer has the formula
- wherein R1 and R2 are independently H, a straight, branched or cyclic alkyl group, or are combined together in a cyclic alkyl group, and R3 is a straight, branched or cyclic alkyl group.
A kit comprising a saleable package comprising:
- a first container that contains a biocompatible adhesive composition comprising at least one alkyl ester cyanoacrylate monomer;
- and
- a polymerization initiator or accelerator, wherein said polymerization initiator or accelerator is a quaternary amine,
- wherein said at least one alkyl ester cyanoacrylate monomer has the formula
- wherein R1 and R2 are independently H, a straight, branched or cyclic alkyl group, or are combined together in a cyclic alkyl group, and R3 is a straight, branched or cyclic alkyl group.
The kit of claim 27, wherein said polymerization initiator or accelerator is contained in a second container.
A method of treating living tissue, comprising:
- applying to internal living tissue in a living organism a biocompatible adhesive composition comprising a polymerization initiator or accelerator and at least one monomer selected from the group consisting of butyl lactoyl cyanoacrylate monomer and butyl glycoloyl cyanoacrylate monomer.
A method of treating living tissue, comprising:
- selecting an alkyl ester cyanoacrylate monomer for treatment of said tissue;
- determining a desired rate at which an adhesive polymer of said monomer is absorbed;
- selecting a suitable polymerization initiator or accelerator for said monomer on the basis of said desired rate;
- and
- applying to living tissue said polymerization initiator or accelerator and said monomer to form an absorbable adhesive polymer on said tissue,
- wherein said alkyl ester cyanoacrylate monomer has the formula
- wherein R1 and R2 are independently H, a straight, branched or cyclic alkyl group, or are combined together in a cyclic alkyl group, and R3 is a straight, branched or cyclic alkyl group.
A biocompatible adhesive composition, comprising:
- at least one alkyl ester cyanoacrylate monomer;
- and
- a polymerization initiator or accelerator, wherein said polymerization initiator or accelerator is a quaternary amine,
- wherein said at least one alkyl ester cyanoacrylate monomer has the formula
- wherein R1 and R2 are independently H, a straight, branched or cyclic alkyl group, or are combined together in a cyclic alkyl group, and R3 is a straight, branched or cyclic alkyl group.
Dependencies are inferred from the claim text.