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US 6,620,804 B2Granted
Selenophene anti-tumor agents
AssigneePurdue Research Foundation
InventorsChing-jer Chang, Curtis L. Ashendel, Darrick Kim
Life of this patent
Estimating the term…
Abstract
Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of; H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
Claims23
A compound of formula I:
- wherein R1 and R2 are independently selected from the group consisting of
- H, CH2OH, CHO and CH2NH2;
- X and Y are independently selected from the group consisting of Se, S, O, and NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the provisos, that R1 and R2 are not both
- and that one of R1 or R2 is
- and when R2 is
- one of R1, R3, R4, R5 and R6 is other than H;
- and when R1 is
- one of R2, R3, R4, R5 and R6 is other than H.
8 more elements
A compound of formula I:
- wherein R1 and R2 are independently selected from the group consisting of
- H, CHO, CH2OH and CH2NH2;
- X and Y are independently selected from the group consisting of Se, S, O and NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5 and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the proviso that R1 and R2 are not both hydrogen and with the proviso that one of R1 or R2 is
- and when R2 is
- R1 is H, CHO, CH2OH or CH2NH2, provided that at least one of R1 R3, R4, R5 and R6 is other than H;
- and when R1 is
- R2 is H, CHO, CH2OH or CH2NH2, provided that at least one of R2, R3, R4, R5 and R6 is other than H.
7 more elements
A pharmaceutical composition comprising a compound of formula I:
- wherein R1 and R2 are independently selected from the group consisting of;
- H, CH2OH, CHO and CH2NH2;
- X and Y are independently selected from the group consisting of Se, S, O and NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5 and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the proviso that R1 and R2 are not both
- and with the proviso that one of R1 or R2 is
- and at least one of R1, R2, R3, R4, R5 or R6 is other than hydrogen and a pharmaceutically acceptable carrier.
5 more elements
A compound of formula I:
- wherein R1 and R2 are independently selected form the group consisting of
- H, CH2OH, CHO and CH2NH2;
- X is Se;
- Y is NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5 and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the provisos, that R1 and R2 are not both
- and with the proviso that one of R1 or R2 is
- and when R2 is
- one of R1, R3, R4, R5 and R6 is other than H;
- and when R1 is
- one of R2, R3, R4, R5 and R6 is other than H.
9 more elements
A compound of formula I:
- wherein R1 and R2 are independently selected from the group consisting of
- H, CHO, CH2OH and CH2NH2 with the proviso that one of R1 or R2 is
- X is Se;
- Y is NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5 and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the proviso that R1 and R2 are not both hydrogen;
- and when R2 is
- R1 is H, CHO, CH2OH or CH2NH2, provided that at least one of R1 R3, R4, R5 and R6 is other than H;
- and when R1 is
- R2 is H, CHO, CH2OH or CH2NH2, provided that at least one of R2, R3, R4, R5 and R6 is other than H.
8 more elements
A pharmaceutical composition comprising a compound of formula I:
- wherein R1 and R2 are independently selected from the group consisting of;
- H, CH2OH, CHO and CH2NH2;
- X is Se;
- Y is NR, wherein R is H or C1-C7 alkyl;
- R3, R4, R5 and R6 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2;
- and when R1, R2, R3, R4, R5 or R6 is CH2NH2, the pharmaceutically acceptable salt of the compound represented thereby;
- with the proviso that R1 and R2 are not both
- and with the proviso that one of R1 or R2 is
- and at least one of R1, R2, R3, R4, R5 or R6 is other than hydrogen;
- and a pharmaceutically acceptable carrier.
7 more elements
Dependencies are inferred from the claim text.