Preparation of optically active α-hydroxyethers
AssigneeSolvias AG
InventorsMartin Studer, Stephan Burkhardt
Life of this patent
Estimating the term…
Abstract
Optically active α-hydroxyethers are prepared from prochiral α-ketoethers by heterogeneous hydrogenation using platinum catalysts in the presence of a chiral nitrogen base in high chemical and optical yields, since this type of hydrogenation selectively hydrogenates only one diastereomer virtually to completion. The yields may be substantially increased by adding a solid, strong base which has a racemizing effect on the non-hydrogenatable diasteromer.
Claims18
Process for heterogeneously and enantioselectively hydrogenating organic α-keto compounds using a platinum catalyst in the presence of a soluble or immobilized chiral aromatic nitrogen base having at least one basic nitrogen atom neighbouring at least one stereogenic carbon atom, characterized in that racemic α-ketoethers are hydrogenated to optically active α-hydroxyethers.
Dependencies are inferred from the claim text.