P-glycoproteins and uses thereof
AssigneeBecton, Dickinson and Company
InventorsPenny J. Stocker, Dorothy T. Steimel-Crespi, Charles L. Crespi
Life of this patent
Estimating the term…
Abstract
The invention pertains to cynomologous monkey P-glycoproteins and related P-glycoproteins which include cynomologous-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the cynomologous monkey P-glycoprotein. The invention further relates to methods of using such cynomologous monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of cynomologous PGP. Also included are cynomologous PGP inhibitors which inhibit cynomologous PGP activity by inhibiting the expression or function of cynomologous PGP.
Claims18
An isolated nucleic acid molecule selected from the group consisting of
- (a) nucleic acid molecules that code for the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4,
- (b) variants of the nucleic acid molecules of (a) that encodes a P-glycoprotein having multidrug transport activity and an amino acid sequence that varies from SEQ ID NO:2 or SEQ ID NO:4 by 1, 2, 3, 4 or 5 amino acid, and
- (c) complements of (a) or (b).
Dependencies are inferred from the claim text.