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US 6,617,444 B1Granted
Dinucleotide tetraphosphate crystals
AssigneeYamasa Corporation
InventorsKenya Mori, Takanori Miyashita, Hideaki Maeda, Hiroshi Sato, Yutaka Noda
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AssigneeYamasa Corporation
InventorsKenya Mori, Takanori Miyashita, Hideaki Maeda, Hiroshi Sato, Yutaka Noda
Estimating the term…
The present invention is directed to crystals of P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for producing dCP4U involving reacting uridine 5′-monophosphate (UMP), 2′-deoxycytidine 5′-monophosphate (dCMP), diphenyl phosphorochloridate (DPC), and pyrophosphate (PPi). The crystals of dCP4U obtained through the process according to the present invention have high purity and high stability and no hygroscopicity as compared with a freeze-dried product, and thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing dCP4U according to the present invention permits use of inexpensive UMP as a raw material and realizes high yield. Thus, the process is suitable for large-scale synthesis of dCP4U.
A crystal of a P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate salt.
A crystal of P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate.4Na.
A process for producing P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate (dCP4U), which process comprises reacting uridine 5′-monophosphate (UMP), 2′-deoxycytidine 5′-monophosphate (dCMP), diphenyl phosphorochloridate (DPC), and a pyrophosphate (PPi),
A crystal which is a hydrate salt having 1-14 molecules of water which are bound to or adhere to one molecule of the P1-(2′-deoxycytidine 5′-)-P4-(uridine 5′-)tetraphosphate salt.
Dependencies are inferred from the claim text.