C8-substituted purine nucleotide analogs
AssigneesBar-Ilan University, Universite de Sherbrooke
InventorsAdrien R. Beaudoin, Fernand-Pierre Gendron, Efrat Halbfinger, Bilha Fischer
Life of this patent
Estimating the term…
Abstract
C8-substituted purine nucleotide analogs, such as ATP analogs, and their use is described, including their use as inhibitors of NTPDases and thereby as tools to modulate the conversion of nucleotides into nucleoside derivatives, and thus modulate the levels of these compounds. Such modulation further provides for the modulation of the activity and function of many processes which are affected by these compounds.
Claims3
A C8-substituted adenine nucleotide, wherein the adenine nucleotide is substituted at the C8 position with a thioether substituent, wherein the thioether substituent has the structure:
- —S—X;
- wherein X is selected from the group consisting of:
- (a) C7H13 (cycloheptyl)
- (b) (CH3)3CCH2;
- and
- (c) CH3(CH2)n, wherein 1≦n≦5.
Dependencies are inferred from the claim text.