Back to results
US 6,617,438 B1Granted
Oligoribonucleotides with enzymatic activity
AssigneeSirna Therapeutics, Inc.
InventorsLeonid Beigelman, Alex B. Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
Life of this patent
Estimating the term…
Abstract
Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
Claims27
An enzymatic nucleic acid molecule having formula III namely:
- wherein each X, Y, and Z represents independently a nucleotide which may be the same or different;
- q is an integer selected from the group consisting of 4, 5, 6, 7, 8, 9, 10, 11, 12, and 15;
- n is an integer ranging from 1 to 10;
- o is an integer ranging from 3-100;
- Z′ is a nucleotide complementary to Z;
- each X(q) and X(o) are oligonucleotides which are of sufficient length to stably interact independently with a target nucleic acid sequence;
- W is a linker ranging from 2 to 70 nucleotides in length or may be a non-nucleotide linker;
- A, U, G, and C represent nucleotides;
- C is 2′-amino;
- and_represents a chemical bond or chemical linkage.
7 more elements
Dependencies are inferred from the claim text.