Loading patent…
AssigneeFraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
InventorsAfroditi Kapurniotu, Jurgen Bernhagen, Herwig Brunner
Estimating the term…
Calcitonins and calcitonin derivatives such as are employed for therapy for, for example, osteoporosis. Paget's disease or hypercalcemia. The calcitonins and calcitonin derivatives are distinguished by a bridging of the amino acids present in the positions 17 and 21. In this case, by means of a suitable choice of the amino acids present in these positions an 18- or 19-membered ring is produced. This ring leads to an increased conformational stability and to an increased activity of the modified calcitonin. A particularly suitable hCt (human Ct) analog is the cyclo17,21-[Asp17, Orn21]-hCt according to the invention having a 19-membered ring structure between the lactam-bridged Asp17 and Orn21.
A calcitonin derivative having a bridge between amino acids in positions corresponding to positions 17 and 21 of human calcitonin, wherein the amino acids in positions 17 and 21 are selected from the group consisting of aspartic acid and orinithine wherein the amino acids positions 17 and 21 are different and wherein the amino acids are arranged in these positions so that the ring formed by the bridge has 19 members.
Dependencies are inferred from the claim text.