Preparation for nasal administration
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsShusei Ito, Kenji Yamada, Ayumi Koda, Mari Nakano
Life of this patent
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Abstract
A preparation for nasal administration which comprises as an effective ingredient a prostaglandin derivative represented by Formula (I): wherein X is a halogen atom, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with C1-4 alkyl group(s) or a C4-13 cycloalkylalkyl group, R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, m is an integer of 0 to 3, and n is an integer of 1 to 4 or a pharmaceutically acceptable salt thereof and a water-soluble polymer.
Claims16
A preparation for nasal administration which comprises as an effective ingredient a prostaglandin compound represented by Formula (I):
- wherein X is a halogen atom, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with C1-4 alkyl group(s) or a C4-13 cycloalkylalkyl group, R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, m is an integer of 0 to 3, and n is an integer of 1 to 4 or a pharmaceutically acceptable salt thereof and a water-soluble polymer, which is at least one member selected from the group consisting of a bridged polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl cellulose, a hydroxyalkylmethyl cellulose, hydroxyethyl cellulose, ethylhydroxyethyl cellulose, carboxymethylhydroxyethyl cellulose and cationic cellulose ether.
A preparation for nasal administration which comprises as an effective ingredient a prostaglandin compound represented by Formula (A):
- or a pharmaceutically acceptable salt thereof and a water-soluble polymer, which is at least one member selected from the group consisting of a bridged polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl cellulose, a hydroxyalkylmethyl cellulose, hydroxyethyl cellulose, ethylhydroxyethyl cellulose, carboxymethylhydroxyethyl cellulose and cationic cellulose ether.
A method for inducing sleep which comprises administering nasally a pharmaceutically effective amount of a sleep-inducing preparation to a human, wherein the sleep-inducing preparation comprises as an effective ingredient a prostaglandin compound represented by Formula (I):
- wherein X is a halogen atom, R1 is a C3-10 cycloalkyl group, a C1-10 cycloalkyl group substituted with C1-4 alkyl group(s) or a C4-13 cycloalkylalkyl group, R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, m is an integer of 0 to 3, and n is an integer of 1 to 4 or a pharmaceutically acceptable salt thereof and a water-soluble polymer.
A method for sleep-inducing which comprises administering nasally a pharmaceutically effective amount of a sleep-inducing preparation to a human, wherein the sleep-inducing preparation comprises as an effective ingredient a prostaglandin compound represented by Formula (A):
- or a pharmaceutically acceptable salt thereof and a water-soluble polymer.
Dependencies are inferred from the claim text.