Use of nitroxides for the treatment of essential hypertension

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver a bolus dose intravenously of about 0.025 mg/kg to about 400 mg/kg.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver a bolus dose intravenously of about 0.025 mg/kg to about 40 mg/kg.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver a bolus dose intravenously of about 0.25 mg/kg to about 4 mg/kg.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver an intravenous dose of about 0.05 mg/kg/hr to about 1000 mg/kg/hr by intravenous infusion.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver an intravenous dose of about 0.05 mg/kg/hr to about 100 mg/kg/hr by intravenous infusion.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Tempol, wherein said Tempol is formulated to deliver an intravenous dose of about 0.5 mg/kg/hr to about 10 mg/kg/hr by intravenous infusion.

A method of treating essential hypertension comprising administering to a patient in need thereof a therapeutically effective amount of a patch for dermal administration of Tempol wherein said Tempol is formulated to provide about 200 mg per square centimeter of said patch.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising the step of administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising Tempo, Tempol, Doxyl or Proxyl, wherein said Tempo, Tempol, Doxyl or Proxyl is formulated to deliver an oral daily dose of about 0.07 mg/kg/day to about 7500 mg/kg/day.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising the step of administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising Tempo, Tempol, Doxyl or Proxyl, wherein said Tempo, Tempol, Doxyl or Proxyl is formulated to deliver an intravenous bolus dose of about 0.025 mg/kg to about 400 mg/kg.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising the step of administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising Tempo, Tempol, Doxyl or Proxyl, wherein said Tempo, Tempol, Doxyl or Proxyl is formulated to deliver a dose of about 0.05 mg/kg/hr to about 1000 mg/kg/hr by intravenous infusion.

A method of treating hypertension, a hypertensive emergency, a hypertensive crisis or essential hypertension comprising the step of administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising Tempo, Tempol, Doxyl or Proxyl, wherein said Tempo, Tempol, Doxyl or Proxyl is formulated for delivery transdermally via a patch, wherein said Tempo, Tempol, Doxyl or Proxyl is present on said patch at a concentration of about 200 mg per square centimeter of said patch.