Preparation and drug composition of bis-benzyl-isoquinoline class alkaloids

A bis-isoquinoline alkaloid compound of formula (I) and salts thereof,

• wherein:
• R1 is hydrogen, straight chain or branched chain alkyl containing 1-10 carbon atoms;
• R2 and R3 are hydrogen, substituted acyl, straight chain or branched chain alkane in which the alkane is optionally interrupted by replacement with heterogeneous atoms O, N, or S, or R2 and R3 in combination comprise a ketone or thioketone;
• R4 and R5 are each selected from the group consisting of a hydrogen, a substituted acyl, a straight chain or branched chain alkyl in which the alkyl chain is optionally interrupted by replacement with a heterogeneous atom N or S, or R4 and R5 in combination consisting of a thioketone;
• X1, X2, X3 and X4 are same or different, and can be individually substituted by a halogen or substituted by straight or branched chain alkyloxy or acyloxy groups containing 1-10 carbon atoms, further wherein when R4 and R5 are both hydrogen, either (a) any one of X1, X2, X3 and X4 is a halogen or (b) X1 is a straight or branched chain alkyloxy or acyloxy group, the alkyloxy group containing at least 3 carbon atoms;
• C(1) and C(1′) are any possible combination of all stereoisomers of C(1) and C(1′);
• and
• n is an integer between 1 and 4 for X2, n is an integer between 0 and 4 for X4, and n is an integer between 1 and 3 for X1 and X3.