Tan-1057 derivatives

Compounds of the formula:

• in which
• R1 represents hydrogen or (C1-C6)alkyl,
• X represents a group of the formula —(CH2)m—, in which m is 1 or 2,
• D is selected from groups of the formulae D1 to D3
• in which R2 represents hydrogen or hydroxyl,
• R3 represents hydrogen, or
• R2 and R3 together form an oxo group,
• Y represents a straight-chain or branched (C1-C5)alkanediyl group which may optionally be substituted by hydroxyl or oxo, or represents a group of the formula below
• in which r and s are identical or different and are 0, 1 or 2,
• Z represents a group selected from groups of the formulae
• in which R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 in each case independently of one another are selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C4)alkanoyl, t-butoxycarbonyl, benzyloxycarbonyl and benzyl,
• Q represents oxygen or sulphur and
• p is 1, 2 or 3 and
• with the proviso, that
• R1 does not represent methyl, m does not represent 1, D does not represent D1 and Y does not represent —(CH2)3— when Z represents a group of the formula
• and pharmaceutically acceptable salts thereof.