Oligosaccharides, their preparation and pharmaceutical compositions containing them
AssigneeAventis Pharma S.A.
InventorsPierre Mourier, Elisabeth Perrin, Jean-marie Stutzmann, Christian Viskov, Florence Wahl
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Abstract
The present invention relates to oligosaccharides of formula: to mixtures thereof, to diastereoisomers thereof, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in preventing or treating a disease associated with an inflammatory process involving the production of nitric oxide.
Claims35
A purified oligosaccharide of formula:
- in which n is 0 or is an integer from 1 to 25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium.
A process for preparing an oligosaccharide of formula:
- or mixtures thereof, in which n is 0 or is an integer from 1 to 25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium, comprising reacting an alkali metal hydroxide or quaternary ammonium hydroxide with an oligosaccharide of formula:
- or a mixture thereof, in which n , R1, R2, R3, R4, R5, R6 and M are as defined in formula I.
A composition comprising one or more purified oligosaccharides of formula:
- or diastereoisomers thereof, in which n is 0 or is an integer from 1 to 25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium.
An oligosaccharide of formula:
- or mixtures thereof, in which n is 0 or is an integer from 1 to 25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium, made by a process comprising reacting an alkali metal hydroxide or quaternary ammonium hydroxide with an oligosaccharide of formula:
- or a mixture thereof, in which n, R1, R2, R3, R5, R6 and M are as defined in formula I.
An oligosaccharide of formula:
- in which n is 2-25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium.
A composition comprising one or more oligosaccharides of formula:
- or diastereoisomers thereof, in which n is 2-25, R1, R3, R4 and R5, which may be identical or different, represent a hydrogen atom or an SO3M radical;
- R2 and R6, which may be identical or different, represent a hydrogen atom or a radical selected from SO3M and COCH3 and M is sodium, calcium, magnesium or potassium.
Dependencies are inferred from the claim text.