Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
AssigneeBristol-Myers Squibb Pharma Company
InventorsRobert F. Kaltenbach, George L. Trainor
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Abstract
This invention relates generally to phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as HIV protease inhibitors, pharmaceutical compositions comprising the same, and methods of using the same for treating viral infection.
Claims30
A compound of formula I:
- or a pharmaceutically acceptable salt form thereof, wherein:
- R1 is F or H;
- R2 is F or H;
- and,
- R3 is selected from the group:
- 4-aminophenyl, 3-aminophenyl, 2,3-dihydrobenzofuran-5-yl, and 1,3-benzodioxol-5-yl;
- and,
- R4 is selected from the group PO3H2, PO3HNa, PO3HK, PO3Na2, and PO3K2.
A pharmaceutical composition useful for the treatment of HIV infection, wherein the reverse transcriptase inhibitor is selected from the group AZT, efavirenz, and 3TC and the protease inhibitor is selected from the group saquinavir, ritonavir, nelfinavir, and indinavir.
A pharmaceutical composition useful for the treatment of HIV infection, wherein the reverse transcriptase inhibitor is AZT.
A pharmaceutical composition useful for the treatment of HIV infection, wherein the protease inhibitor is ritonavir.
Dependencies are inferred from the claim text.