Methods for diagnosing and treating autoimmune disease
AssigneeThe General Hospital Corporation
InventorsDenise L. Faustman, Takuma Hayashi
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Abstract
The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. In addition, the invention encompasses a method of treating an autoimmune disease in a mammal, comprising administering to a mammal suspected of suffering from an autoimmune disease an agent which restores NFκB activity in an amount and for a time sufficient to result in normal NFκB activity in the mammal.
Claims4
A method of screening for autoimmune disease associated with a reduction in NFκB activity in a mammal deemed to be at risk for an autoimmune disease comprising:
- a) providing a biological sample from a mammal;
- and
- b) measuring the level of proteolytic products derived from the proteolytic processing of NFκB in said sample, wherein a reduction in the level of said proteolytic products from a basal state is correlated with the presence of an autoimmune disease associated with a reduction in NFκB activity.
Dependencies are inferred from the claim text.