Measurement of accelerated whole blood clotting time
AssigneeProphylaxis Limited
InventorCharles Richardson White Gray
Life of this patent
Estimating the term…
Abstract
Disclosed is The method of in vitro testing of the state of the blood coagulation system. The Accelerated Whole Blood Clotting Time (A. W. B. C. T.) reflects the degree of over or under activity of the coagulation system of the blood.
Claims13
A method of in vitro screening and/or monitoring of a whole blood clotting time of a patient comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists, and
- c. measuring the whole blood clotting time of the whole blood sample, wherein a degree of an overactive or underactive coagulation system is assessed.
A method of monitoring patients on an anticoagulant therapy comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an overactive coagulation system due to the anticoagulant therapy is assessed.
A method of identifying patients with overactive coagulation systems comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an overactive coagulation system is assessed.
A method of measuring an effect of a diet on a coagulation system of a patient suffering from haemophilia comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an underactive coagulation system due to the diet of the patient is assessed.
A method of monitoring the acute or prophylactic treatment of Haemophilia with Factor VIII in a patient comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an underactive coagulation system due to the acute or prophylactic treatment of Haemophilia with Factor VIII in the patient is assessed.
A method of assessing a degree of risk of suffering a thrombosis in a patient comprising the steps of:
- a. collecting a whole blood sample from the patient;
- adding one or more physiological/pathological platelet agonists exclusively either to the whole blood sample within two minutes of collection or to a citrated whole blood sample from the sample recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an overactive coagulation system, indicating a risk of suffering a thrombosis in the patient, is assessed.
A method of measuring an effect of smoking on a whole blood clotting time of a patient comprising the steps of:
- a. collecting a whole blood sample from the patient;
- b. adding one or more physiological/pathological platelet agonists exclusively either to the whole blood within two minutes of collection or to a citrated whole blood sample from the patient recalcified immediately prior to addition of the one or more platelet agonists;
- and
- c. measuring a whole blood clotting time of the whole blood sample, wherein a degree of an overactive coagulation system due to smoking by the patient is assessed.
Dependencies are inferred from the claim text.