Methods and compositions for the selective modification of nucleic acids
AssigneeV.I. Technologies, Inc.
InventorsEdward I. Budowsky, Samuel K. Ackerman, Andrei A. Purmal, Clark M. Edson
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Abstract
Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
Claims4
A nucleic acid inactivating agent having the formula:
- ω−X1−[R1−N30(R2, R3)−]nR4·(X2−)n,
- wherein X1 is Cl or Br;
- R1 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive;
- each of R2, R3, and R4 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R2, R3, and R4 cannot all be H when R1 contains 2 carbon atoms;
- X2 is a pharmaceutically acceptable counter-ion;
- and n is an integer between 2 and 10, inclusive.
Dependencies are inferred from the claim text.