Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics
OwnerLynn A. Doucette-Stamm, David Bushinventors
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Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Enterococcus faecalis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Claims19
An isolated nucleic acid comprising a nucleotide sequence encoding an E. faecalis polypeptide selected from the group consisting of SEQ ID NO:5177, SEQ ID NO:4597, SEQ ID NO:6122, and SEQ ID NO:4420.
An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:1772, SEQ ID NO:2248, SEQ ID NO:93, SEQ ID NO:1192, SEQ ID NO:1645, SEQ ID NO:1773, SEQ ID NO:2717, SEQ ID NO:2917, and SEQ ID NO:1015.
An isolated nucleic acid comprising a nucleotide sequence which can be used to detect the presence of E. faecalis in a sample, wherein said nucleic acid shares at least 90% homology to a sequence selected from the group consisting of SEQ ID NO:93, SEQ ID NO:1645, SEQ ID NO:1773, SEQ ID NO:2917, and SEQ ID NO:1015.
An isolated nucleic acid comprising a nucleotide sequence which can be used to detect the presence of E. faecalis in a sample, wherein said nucleic acid shares at least 95% homology to a sequence selected from the group consisting of SEQ ID NO:93, SEQ ID NO:1645, SEQ ID NO:1773, SEQ ID NO:2917, and SEQ ID N:1015.
An isolated nucleic acid comprising SEQ ID NO:2594.
An isolated nucleic acid comprising a nucleotide sequence which can be used to detect the presence of E. faecalis in a sample, wherein said nucleic acid shares at least 95% homology to SEQ ID NO:2594.
Dependencies are inferred from the claim text.