Human cystatin E polynucleotides
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Reiner L. Gentz, Guo-Liang Yu, Craig A. Rosen
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Abstract
Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
Claims69
An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide having a first amino acid sequence 90% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) amino acid residues 1-149 of SEQ ID NO:2;
- (b) amino acid residues 29-149 of SEQ ID NO:2;
- (c) the amino acid sequence of the full-length polypeptide encoded by the cDNA clone contained in ATCC® Deposit No. 97156;
- and
- (d) the amino acid sequence of the mature polypeptide encoded by the cDNA clone contained in ATCC® Deposit No. 97156;
- wherein the polypeptide has cysteine protease inhibitor activity.
An isolated polynucleotide consisting of at least 30 contiguous nucleotides of SEQ ID NO:1, or the complementary strand thereto.
An isolated polynucleotide consisting of at least 30 contiguous nucleotides of the cDNA contained in ATCC® Deposit No. 97156, or the complementary strand thereto.
An isolated polynucleotide comprising a nucleotide sequence encoding the amino acid sequence of the full-length polypeptide encoded by the cDNA clone contained in ATCC® Deposit No. 97156.
Dependencies are inferred from the claim text.