Human NK-3 related prostate specific gene-1
AssigneeHuman Genome Sciences, Inc.
InventorsWei-Wu He, Kenneth C. Carter
Life of this patent
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Abstract
The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.
Claims137
An isolated polynucleotide comprising a nucleic acid encoding amino acids 2 to 234 of SEQ ID NO:2.
An isolated polynucleotide comprising a nucleic acid encoding amino acids 2 to 234 of SEQ ID NO:4.
An isolated polynucleotide comprising a nucleic acid encoding the complete amino acid sequence encoded by the cDNA clone in ATCC Deposit No. 209006.
An isolated polynucleotide comprising a nucleic acid selected from the group consisting of:
- (a) a nucleic acid encoding amino acids 1 to 13 of SEQ ID NO:2;
- (b) a nucleic acid encoding amino acids 103 to 113 of SEQ ID NO:2;
- (c) a nucleic acid encoding amino acids 117 to 130 of SEQ ID NO:2;
- and
- (d) a nucleic acid encoding amino acids 173 to 185 of SEQ ID NO:2;
- wherein said nucleic acid encodes a polypeptide which specifically binds an antibody that specifically binds a polypeptide consisting of amino acids 1 to 234 of SEQ ID NO:2.
An isolated polynucleotide consisting of a nucleic acid encoding at least 30 contiguous amino acids of SEQ ID NO:2.
An isolated polynucleotide consisting of a nucleic acid encoding at least 30 contiguous amino acids of SEQ ID NO:4.
An isolated polynucleotide consisting of at least 40 contiguous nucleotides of SEQ ID NO:1.
An isolated polynucleotide consisting of at least 40 contiguous nucleotides of SEQ ID NO:3.
An isolated polynucleotide consisting of a nucleic acid encoding at least 30 contiguous amino acids of the amino acid sequence encoded by the cDNA clone in ATCC Deposit No. 209006.
An isolated polynucleotide consisting of at least 40 contiguous nucleotides of the nucleotide sequence of the cDNA clone contained in ATCC Deposit No. 209006.
An isolated polynucleotide consisting of at least 40 contiguous nucleotides of SEQ ID NO:8.
An isolated polynucleotide comprising the complete nucleotide sequence of SEQ ID NO:8.
An isolated polynucleotide consisting of at least 40 contiguous nucleotides of the nucleotide sequence of the genomic clone contained in ATCC Deposit No. 209005.
An isolated polynucleotide comprising the complete nucleotide sequence of the genomic clone contained in ATCC Deposit No. 209005.
An isolated polynucleotide comprising a nucleic acid selected from the group consisting of:
- (a) a nucleic acid encoding amino acids 35 to 89 of SEQ ID NO:2;
- (b) a nucleic acid encoding amino acids 35 to 89 of SEQ ID NO:4;
- and
- (c ) a nucleic acid encoding amino acids 122 to 188 of SEQ ID NO:2.
Dependencies are inferred from the claim text.