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US 6,617,128 B2Granted
Nucleic acid molecules encoding proteins which impart the adhesion of neisseria cells to human cells
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsThomas F. Meyer, Thomas Rudel, Ina Scheuerpflug, Jurgen Maier, Sandra Eickernjager, Thomas Schwan, Eckhard Fischer
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Abstract
Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid molecules and antibodies directed against them. Furthermore, pharmaceutical compositions, vaccines and diagnostic compositions containing the nucleic acid molecules, proteins and/or antibodies are described.
Claims11
An isolated nucleic acid molecule selected from the group consisting of
- (a) a nucleic acid molecule comprising the nucleotide sequence depicted in SEQ ID NO:
- 1;
- (b) a nucleic acid molecule comprising a nucleotide sequence having 95% sequence identity to SEQ ID NO:1 due to the degeneracy of the genetic code;
- and
- (c) a nucleic acid molecule comprising a nucleotide sequence that hybridizes under stringent hybridization conditions of 0.2×SSC, 0.1% SDS and 68° C. to the complement of SEQ ID NO:
- 1;
- wherein an open reading frame contained in the nucleic acid molecule encodes a protein from bacteria of the genus Neisseria that mediates the adhesion of Neisseria cells to human cells.
4 more elements
Dependencies are inferred from the claim text.