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US 6,617,124 B1Granted
7-alkoxycoumarins as cytochrome p450 substrates
AssigneeSmithKline Beecham Corporation
InventorStephen Edward Clarke
Life of this patent
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Abstract
Coumarin derivatives as substrates for cytochrome P450 enzyme.
Claims5
An assay for testing for inhibitors of the enzyme CYP2D6 which comprises contacting the enzyme and a compound of formula (I):
- wherein R1 and R2 independently represent hydrogen or C1-2alkyl and R3 is C1-2alkyl, with a test compound and measuring inhibition of O-dealkylation of the compound of formula (I) by the enzyme.
Dependencies are inferred from the claim text.