Snail, new tumoral progression marker and target protein of new antitumoral compounds
AssigneesConsejo Superior de Investigaciones Cientificas, Universidad Autonoma De Madrid
InventorsAmparo Cano García, Ma Angela Nieto Toledano, Ma Isabel Rodrigo Castro, Annamaria Locascio, Marta García del Barrio, María José Blanco Fernandez de Valderrama, Francisco Portillo Pérez, Mirna Alicia Pérez Moreno
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Abstract
The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumor cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumor marker, indicative of tissue invasion and metastatic capacity.
Claims4
A method for determining the invasive and metastatic capacity of an epithelial tumour, said method comprising:
- a. obtaining a biological sample from said epithelial tumour;
- b. determining whether a diagnostic marker, Snail, is present in said biological sample;
- and
- c. comparing said diagnostic marker determined to be present in said biological sample with its absence in a control sample, the presence of said marker in said biological sample being indicative of the invasive and metastatic capacity of said epithelial tumour.
Dependencies are inferred from the claim text.