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US 6,617,120 B2Granted
Method of conferring 9-CIS retionic acid reponsiveness
AssigneeKaro Bio AB
InventorsEva L. K. Enmark, Jan-Ake Gustafsson
Life of this patent
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Abstract
This invention provides an isolated receptor having the amino acid sequence of FIG. 1 (SEQ ID NO:2) or substantially the same amino acid sequence as the amino acid sequence shown in FIG. 1 (SEQ ID NO:2) or an amino acid sequence functionally similar to that sequence, and DNA sequences encoding such a receptor.
Claims5
A method of conferring 9-cis retinoic acid responsiveness, comprising the steps of transforming cells in vitro with an isolated nuclear receptor comprising a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- and administering 9-cis retinoic acid to the cells to achieve activation of the retinoic acid X receptor (RXR).
Dependencies are inferred from the claim text.