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US 6,617,104 B2Granted
Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus
OwnerMichael R. Swiftinventor
Life of this patent
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Abstract
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to the discovery that some alleles of the A-T gene cause susceptibility to cancer, in particular breast cancer. More specifically, the present invention relates to germline mutations in the A-T gene and their use in the diagnosis of predisposition to breast cancer. The invention further relates to somatic mutations in the A-T gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer.
Claims12
A method for predicting a predisposition to breast cancer in an individual comprising:
- determining the presence of an alteration in the germline A-T nucleic acid sequence from said individual as compared to the wildtype germline A-T nucleic acid sequence, wherein the germline alteration is an A-T susceptibility allele statistically associated with a predisposition to breast cancer.
Dependencies are inferred from the claim text.