Solid phase quenching systems
AssigneeV.I. Technologies, Inc.
InventorsAndrei A. Purmal, Samuel K. Ackerman
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Abstract
The invention features a method of inactivating a contaminant, such as a virus, of a biological composition. The method includes the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety or a haloderivative salt thereof, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a composition which includes one quenching moiety under conditions and for a time sufficient to allow the inactivating agent to bond covalently to the quenching moiety; and (c) separating the quenching moiety and the quenched inactivating agent from the biological composition.
Claims19
A method of inactivating a contaminant of a biological composition comprising the steps of:
- (a) contacting the biological composition with an inactivating agent, said agent comprising an aziridino moiety or a haloderivative salt thereof, where a portion of said agent reacts with and inactivates said contaminant, and a portion of said agent remains unreacted;
- (b) contacting the product of step (a) with a quenching agent comprising a quenching moiety, under conditions and for a time sufficient to allow said inactivating agent to bond covalently to said quenching moiety;
- and
- (c) separating said quenching agent and said quenched inactivating agent from the biological composition.
A method of inactivating a contaminant of a biological composition comprising the steps of:
- (a) contacting the biological composition with an inactivating agent, said agent comprising an aziridino moiety or a haloderivative salt thereof, where a portion of said agent reacts with and inactivates said contaminant, and a portion of said agent remains unreacted;
- (b) contacting the product of step (a) with a quenching agent comprising quenching moiety attached to a separation moiety through covalent bonds under conditions and for a time sufficient to allow said inactivating agent to bond covalently to said quenching moiety;
- and
- (c) separating said separation moiety, said quenching moiety and said quenched inactivating agent from the biological composition.
Dependencies are inferred from the claim text.