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US 6,616,944 B2Granted
Self-assembling colloidal carriers for protein delivery
AssigneeMedinnova Gesellschaft fur Medizinsche Innovationen aus Adkademischer Forschung mbH
InventorsThomas Kissel, Armin Breitenbach, Tobias Jung, Walter Kamm
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Abstract
The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol containing six or more hydroxyl groups as a central backbone and biodegradable hydroxy carboxylic ester groups attached to the central backbone.
Claims32
A polyol ester comprising:
- (a) a linear polyol containing greater than six hydroxyl groups as a central backbone;
- (b) biodegradable hydroxy carboxylic ester groups attached to the central backbone,
- (c) wherein the linear polyol contains charged groups, proton donating groups, and/or proton accepting groups, which are attached via a spacer group or an ether-, ester- or urethane-linkage to the linear polyol, and
- (d) wherein the polyol ester has a lower critical solution temperature (LCST) in aqueous solution of between 0 and 100° C.
1 more element
Dependencies are inferred from the claim text.