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US 6,616,927 B2Granted
Processes for production of immunoglobulin A in milk
AssigneeAgResearch Limited
InventorsAlison Joy Hodgkinson, Steven Charles Hodgkinson
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Abstract
The present invention provides a process for production of immunoglobulin A in milk from hyperimmunised mammals, using a three-route immunisation protocol. Also provided is milk containing immunoglobulin A produced by the process of the invention. These products are useful in producing formulations for passive immunisation against the selected pathogens. These formulations are further useful for preparation of further processed products.
Claims33
A process for the production for immunoglobulin A (IgA) in the milk of a ruminant comprising:
- (a) actively immunizing a pregnant ruminant with an antigen by any two routes of administration selected from the group consisting of intra mammary (IMM) intra peritoneal (IP) and intramuscular (TM);
- and
- (b) actively immunizing said ruminant with an antigen by a third administration route selected from the group consisting of intra mammary (IMM), intra peritoneal (IP) and intramuscular (IM);
- with the proviso that all three administration routes are different;
- and
- wherein a higher IgA titre is produced as compared to an IgA titre produced by conducting step (a) alone.
3 more elements
Dependencies are inferred from the claim text.