Methods of modulating lipid metabolism and storage
AssigneeCuris, Inc.
InventorsLinda Burkly, Li Chun Wang
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Abstract
Anti-hedgehog antibodies directed at blocking the binding of hedgehog to its receptor patched-1, will impair lipid metabolism and storage. This invention presents methods for the treatment of a variety of lipid metabolism and lipid storage disorders, aberrant apolipoprotein expression, atherosclerosis and other lipid associated disorders using lipid modulators such as hedgehog antagonists or hedgehog agonists.
Claims8
A method for decreasing lipid absorption in an animal comprising administering to the animal an amount of an anti-hedgehog antibody effective to decrease lipid absorption in said animal.
A method of increasing lipid accumulation in vacuoles in intestinal epithelial cells in an animal comprising administering to the animal an amount of an anti-hedgehog antibody effective to increase the lipid accumulation in vacuoles in intestinal epithelial cells.
A method for increasing the accumulation of fat in intestinal epithelial cells in an animal comprising administering to the animal an amount of an anti-hedgehog antibody effective to increase the accumulation of fat in intestinal epithelial cells.
A method of inducing weight loss in an animal comprising administering to the animal an amount of an anti-hedgehog antibody effective to decrease the weight of said animal.
Dependencies are inferred from the claim text.