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US 6,616,925 B1Granted
Combined preparation for the treatment of neoplasic diseases or of infectious diseases
AssigneeI.D.M. Immuno-Designed Molecules
InventorsJacques Bartholeyns, Yves Fouron, Jean-Loup Romet-Lemonne
Life of this patent
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Abstract
The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts: monocyte derived cells, particularly cytotoxic macrophages, chemotherapy or immunotherapy drugs, for the simultaneous, separate or sequential use, for the treatment of cancer or infectious diseases.
Claims14
A combined preparation consisting essentially of as active substance the following individual components, in the form of a kit-of-parts:
- cytotoxic macrophages, and
- at least one chemotherapy drug selected from the group consisting of anthracyclins, daunorubicin, adriamycin, taxoter derivatives, vinca alcaloids, vincristine, taxol, carmustine, cisplatin, fluorouracils, polyamine inhibitors, topoisomerase inhibitors, tamoxifene, prodasone, sandostatine, sodium butyrate, mitomycin C, penicilins, ∃-lactamines, caphalosporines, cyclines, aminoglucosidescosides, macrolides, sulfamides, AZT, protease inhibitors, acyclovir, retrovir and foscarnet;
- wherein said cytotoxic macrophages are present in said kit-of-parts as a first injectable solution, and wherein said at least one chemotherapy drug is present in said kit-of-parts as a second injectable solution physically separate from said first injectable solution, said macrophages being suspended in said first injectable solution at a concentration yielding a dose of about 107 to about 1010 monocyte derived cells per injection.
Dependencies are inferred from the claim text.