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AssigneeThe Regents of the University of California
InventorsJean M. J. Fréchet, Frantisek Svec, Michael Lämmerhofer
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An electrochromatographic device is provided for conducting enantioselective separation of enantiomers. The device is comprised of a conduit containing a monolithic enantioselective separation medium, and may be, for example, a capillary tube or a microchannel in a substrate. The enantioselective separation medium is prepared by copolymerization of (a1) an ionizable chiral monomer or (a2) a chiral monomer and an ionizable comonomer, along with (b) a crosslinking comonomer and (c) a polymerization initiator, in (d) a porogenic solvent. Following ionization, the enantioselective separation medium serves as a charge carrier as well as a chiral separation medium, and further acts as an electroosmotic pump to facilitate the flow of a fluid. The invention also provides methods for preparing the enantioselective separation medium and electrochromatographic devices fabricated therewith.
A device for use in conducting chiral electrochromatography, comprising an electrochromatographic conduit within which is an enantioselective separation medium comprised of a monolithic, ionizable copolymer that acts as a continuous separation medium and contains pendant chiral selector groups, wherein the pendant chiral selector groups each contain a stereogenic center.
A method for making an electrochromatographic device useful in conducting enantioselective separations, comprising:
A method for making an electrochromatographic device useful in conducting enantioselective separations, comprising:
A method for making a microelectrochromatographic device useful in conducting enantioselective separations, comprising:
A method for making a microelectrochromatographic device useful in conducting enantioselective separations, comprising:
A chiral copolymer suitable for electrochromatographic resolution of racemic compounds, prepared by copolymerization of a mixture comprising (a) an ionizable chiral monomer, (b) a crosslinking comonomer, (c) a polymerization initiator, and (d) a porogenic solvent.
A chiral copolymer suitable for electrochromatographic resolution of racemic compounds, prepared by copolymerization of a mixture comprising (a) a chiral monomer, (b) an ionizable comonomer, (c) a crosslinking comonomer, (d) a polymerization initiator, and (e) a porogenic solvent.
A method for preparing a chiral copolymer useful as an enantioselective separation material, wherein the method comprises admixing an ionizable chiral monomer with a crosslinking comonomer and a polymerization initiator in a porogenic solvent, to form a polymerization mixture, and applying heat or radiation to the polymerization mixture to initiate polymerization.
A method for preparing a chiral copolymer useful as an enantioselective separation material, wherein the method comprises admixing a chiral monomer with an ionizable comonomer, a crosslinking comonomer and a polymerization initiator in a porogenic solvent, to form a polymerization mixture, and applying heat or radiation to the polymerization mixture to initiate polymerization.
Dependencies are inferred from the claim text.