Therapeutic polyanhydride compounds for drug delivery
AssigneeRutgers, The State University of New Jersey
InventorKathryn E. Uhrich
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Abstract
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drugs to a host via the polymeric drug delivery systems.
Claims33
A polymer comprising a backbone, wherein the backbone comprises an anhydride linkage, and wherein the backbone comprises one or more groups that will yield a biologically active compound upon hydrolysis of the polymer;
- provided that the biologically active compound is not an ortho-hydroxy aryl carboxylic acid:
- and provided that the biologically active compound is not an alpha-hydroxy carboxylic acid:
- wherein the biologically active compound is an anti-inflammatory agent, an antibiotic, an anti-fungal agent, an anti-infective, an anti-cancer agent, an anti-thrombotic, an immunomodulator, an antidiabetic agent, an antineoplastic, an antiosteoporotic, an ultraviolet screening agent, or a psychotherapeutic agent.
Dependencies are inferred from the claim text.