Papovavirus pseudocapsids and use thereof for exogenous material transfer
AssigneeImperial College Innovations Limited
InventorsJitka Forstová, Beverly Elayne Griffin, Nina Sheila Krauzewicz
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Abstract
The present invention relates to biologically useful material in the form of a pseudocapsid formed from papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid incorporates exogenous material. The invention also relates to a method of using the pseudocapsids as vectors for exogenous material transfer, especially gene transfer in the therapy of genetic disorders, of other uses such as antibody or drug targeting.
Claims19
A method of transferring material into a host cell comprising:
- providing a pseudocapsid formed from a papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid has exogenous material associated therewith, but excluding a method in which exogenous material is associated with an empty pseudocapsid formed from only the mouse polyoma virus major capsid antigen, VP1;
- and
- treating the host cell with the pseudocapsid so that the material is taken up by the cell and is biologically functional in that cell.
A pseudocapsid formed from papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid has exogenous material associated therewith;
- but excluding pseudocapsids associated with exogenous genetic material and no other exogenous material when the pseudocapsid is formed from only the mouse polyoma virus major capsid antigen VP1.
The pseudocapsid formed from papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid has exogenous material associated therewith, wherein the pseudocapsid transfers the exogenous material into a host cell so that the material is taken up by the cell and is biologically functional in the cell;
- but excluding pseudocapsids associated with exogenous genetic material and no other exogenous material when the pseudocapsid is formed from only the mouse polyoma virus major capsid antigen VP1.
Dependencies are inferred from the claim text.