Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property

A method for identifying a compound suppressing the negative feedback mechanism of brain somatostatin release, comprising:

• contacting a nerve cell sample with somatostatin, and a second nerve cell sample with somatostatin and said compound,
• comparing membrane potential-dependent calcium current of the cell sample contacted with somatostatin, with the membrane potential-dependent calcium current of the second cell sample contacted with somatostatin and said compound,
• and selecting a compound which decreases the suppressive effect of somatostatin on said membrane potential-dependent calcium current, thereby identifying a compound suppressing the negative feedback mechanism of brain somatostatin release,
• with the proviso that the compound is not N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide (FK-960) or a compound of formula (I):
• wherein R1 methyl,
• A is —CO—,
• R2 is hydrogen,
• Y is —SO2—, and
• R3 is phenyl substituted with fluorine.

A method for expressing long-term potentiation of synaptic transmission, comprising:

• the step of administering to a tissue in need thereof, a means for exerting an action to promote release of a brain somatostatin through suppression of a negative feedback mechanism of the brain somatostatin release,
• with the proviso that said means is not N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide (FK-960) or a compound of formula (I):
• wherein R1 is methyl,
• A is —CO—,
• R2 is hydrogen,
• Y is —SO2—, and
• R3 is phenyl substituted with fluorine.

A method for identifying a compound expressing long-term potentiation of synaptic transmission, comprising:

• the step of subjecting said compound to a means for determining whether said compound suppresses the negative feedback mechanism of brain somatostatin release,
• and the step of selecting a compound which suppresses the negative feedback mechanism of brain somatostatin release thereby identifying a compound expressing long-term potentiation of synaptic transmission,
• with the proviso that the compound is not N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide (FK-960) or a compound of formula (I):
• wherein R1 is methyl,
• A is —CO—,
• R2 is hydrogen,
• Y is —SO2—, and
• R3 is phenyl substituted with fluorine.

A method for expressing long-term potentiation of synaptic transmission, comprising:

• administering to a tissue in need thereof, an effective amount of a compound of formula (I):
• wherein
• R1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic group, each of which may be substituted with halogen,
• R2 is a hydrogen atom or lower alkyl,
• R3 is cyclo(lower)alkyl, aryl or ar(lower)alkyl, each of which may be substituted with halogen,
• A is —CO—, —SO2— or lower alkylene, and
• Y is —CO—, —SO2— or —CONH—
• wherein said compound exerts an action to promote release of a brain somatostatin through suppression of a negative feedback mechanism of brain somatostatin release, with the proviso that the compound is not N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide (FK-960) or a compound of formula (I):
• wherein R1 is methyl,
• A is —CO—,
• R2 is hydrogen,
• Y is —SO2—, and
• R3 is phenyl substituted with halogen.