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US 6,611,767 B1Granted
Scanned image alignment systems and methods
AssigneeAffymetrix, Inc.
InventorsPeter Fiekowsky, Dan M. Bartell
Life of this patent
Estimating the term…
Abstract
Systems and methods for aligning scanned images are provided. A pattern is included in the scanned image so that when the image is convolved with a filter, a recognizable pattern is generated in the convolved image. The scanned image may then be aligned according to the position of the recognizable pattern in the convolved image. The filter may also act to remove the portions of the scanned image that do not correspond to the pattern in the scanned image.
Claims23
A method of aligning images, comprises:
- synthesizing a chip having attached nucleic acid sequences, the chip including a first pattern of nucleic acid sequences;
- hybridizing labeled nucleic acid sequences to nucleic acid sequences on the chip;
- scanning the hybridized chip to produce a scanned image;
- convolving the scanned image with a filter, the filter convolving the first pattern into a second pattern in a convolved image;
- and
- aligning the scanned image to an image of the chip according to a position of the second pattern in the convolved image.
3 more elements
A computer program product that aligns images, comprising:
- computer code that receives as input a scanned image of a chip having attached nucleic acid sequences to which labeled nucleic acid sequences are hybridized, the chip including a first pattern of nucleic acid sequences;
- computer code that convolves the scanned image with a filter, the filter convolving the first pattern into a second pattern in a convolved image;
- computer code that aligns an image of the scanned image to the chip according to a position of the second pattern in the convolved image;
- and
- a computer readable medium that stores the computer codes.
2 more elements
Dependencies are inferred from the claim text.