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US 6,610,882 B2Granted
N-(arylsulphonyl) amino acid derivatives
AssigneeSanofi-Synthelabo
InventorsBernard Ferrari, Jean Gougat, Claude Muneaux, Yvette Muneaux, Pierre Perreaut, Claudine Planchenault
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in claim 1. These compounds are pharmacologically active.
Claims2
A compound of formula:
- in which
- R1 is naphthyl, or tetrahydronaphthyl, said rings being unsubstituted or substituted one or more times with R10
- R2 is a phenyl which is unsubstituted or substituted one or more times with R11, a phenyl(C1-C4)alkyl which is unsubstituted or substituted one or more times on the phenyl with R11, a naphthyl which is unsubstituted or substituted one or more times with R11, a cyclohexyl which is unsubstituted or substituted one or more times with R11;
- R3 is hydrogen or a hydroxyl;
- R9 is hydrogen, a (C1-C4)alkyl or a phenyl(C1-C4)alkyl which is unsubstituted or substituted on the phenyl one or more times with R11;
- R10 is a halogen, a (C1-C4)alkyl, a (C1-C4)alkoxy, a hydroxyl, an amino, a (C1-C4)alkylamino or a di(C1-C4)alkylamino;
- R11 is a halogen, a (C1-C4)alkyl, a trifluoromethyl, a phenyl, a hydroxyl, a (C1-C4)alkoxy or a benzyloxy;
- or R11 is in the ortho position to the phenyl representing R2 and forms with R3 a methylene group or an ethylene group;
- or R11 is in the ortho position to the phenyl representing R2 and forms with R9 a methylene group or an ethylene group,
- C* is an asymmetric carbon atom;
- as well as the salts thereof with inorganic or organic acids.
8 more elements
Dependencies are inferred from the claim text.