Copper-catalyzed enantioselective allylic substitution reactions
AssigneeAvecia Limited
InventorsFrank Duebner, Paul Knochel
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Abstract
An allylic compound is reacted with an organozinc compound Zn(R6)2 to eliminate a group (the leaving group) from the allylic compound and to add a group from the organozinc compound to it in the presence of a copper salt catalyst and a chiral organic ligand for the copper. A novel ferrocenyl compound and a novel copper complex of the ferrocenyl compound and copper are also described.
Claims26
A process in which an allylic compound is reacted with an organozinc compound to eliminate a group (the leaving group) from the allylic compound and to add a group from the organozinc compound to it in the presence of a copper salt catalyst and a chiral organic ligand for the copper.
A compound of formula
- in which A is a ferrocenyl or substituted ferrocenyl group and B is an aryl group other than a phenyl group.
A complex which comprises a compound of formula
- in which A is a ferrocenyl or substituted ferrocenyl group and B is an alkyl group or aryl group other than a methyl group or phenyl group, and copper.
Dependencies are inferred from the claim text.