Post-Amadori inhibitors of advanced glycation reactions

A compound of the formula

• wherein R1, R1′, R5, and R5′ are independently selected from the group consisting of (CH2)nX wherein n is between 0 and 6 and X is H, OH, SH, COOH or NH2;
• and mono-, di-, or tri-halogenated C1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkenyl;
• with the proviso that at least one R1, R1′, R5, and R5′ is selected from the group consisting of OH, SH, and NH2;
• wherein R2, R2′, R4 and R4′ are independently selected from the group consisting of (CH2)nZ, wherein n has the meaning given above and Z is H, OH, SH, COOH, or NH2;
• and mono-, di-, or tri-halogenated C1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkenyl;
• wherein R3 and R3′ are independently selected from the group consisting of H and mono-, di-, or tri-halogenated C1-6 alkyl, or are absent;
• wherein R6 and R6′ are (CH2)x, wherein x is between 1 and 6;
• wherein R7 is selected from NH and HOP═O;
• or wherein R6, R6′, and R7 combine to form an aryl group, heteroaryl group, or
• or a pharmaceutically acceptable salt thereof;
• wherein the compound is not dipyridoxylamine;
• and
• wherein if R7 is NH, R6 and R6′ are CH2, and one of R5 or R5′ is OH, then the other of R5 and R5′ is selected from the group consisting of (CH2)nX wherein n is between 0 and 1 and X is H, OH, SH, COOH or NH2;
• and mono-, di-, or tri-halogenated C 1-6 alkoxy, or C 1-6 alkenyl.