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US 6,610,850 B2Granted
Contrast media for angiography
AssigneeThe University of North Carolina at Chapel Hill
InventorsDon A. Gabriel, Laura J. Melton
Life of this patent
Estimating the term…
Abstract
The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
Claims12
A compound of the formula:
- wherein X is
- and R3 is NHCOCH(OH)CH3, N(COCH3)CH2CH(OH)CH2OH, N(COCH2OH)CH2CH(OH)CH2OH, or NHCOCH2OCH3.
A compound of the formula
- wherein X is
- and wherein either (i) R1 is N(CH2CH2OH)CH2CH(OH)CH(OH)CH2OH and R2 is CH(OH)CH2OH or CH(CH2OH)2, or (ii) R1 is N(CH2CH(OH)CH2OH)CH2CH(OH)CH(OH)CH2OH and R2 is CH(OH)CH3.
A compound of the formula
- wherein X is
- and wherein R2 is CH(OH)CH2OH, CH(CH2OH)2, or CH(OH)CH3.
A compound of the formula:
- wherein X is
- and wherein
- R2 is CONHCH(CH2OH)2 and R3 is NHCOCH(OH)CH3,
- R2 is CONHCH2CH(OH)CH2OH and R3 is N(COCH3)CH2CH(OH)CH2OH,
- R2 is CONHCH2CH(OH)CH2OH and R3 is N(COCH2OH)CH2CH(OH)CH2OH,
- R2 is CONHCH2CH2OH and R3 is N(COCH3)CH2CH(OH)CH2OH, or
- R2 is CON(CH3)CH2CHOHCH2OH and R3 is NHCOCH2OCH3.
4 more elements
Dependencies are inferred from the claim text.